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The role We have an exciting opportunity for a talented researcher with a background in molecular and genetic epidemiology to join the Integrative Cancer Epidemiology Programme (ICEP) at the University of Bristol to investigate the value added by human genetics to interrogate the causal role played by the human gut microbiome in cancer aetiology. Building on the current work of Kaitlin and her growing team, this Research Associate (Grade I) position is funded by Cancer Research UK (CRUK) as part of a Population Research Postdoctoral Fellowship awarded to Dr Kaitlin Wade. The post holder will be covering a vacant position for the remaining 17 months of funding. What will you be doing? The post holder will continue and lead projects within this programme of research, including gathering and appraising host genetic contributions to the gut microbiome using genome-wide association studies (GWAS) and expertise from collaborators, applying contemporary causal inference methodologies to challenge the role of the gut microbiome in cancer aetiology, examining the likely effects of reverse causation in these relationships and assessing the association between genome-wide predictors of the gut microbiome and cancer risk outside a causal framework. Specifically, this research will involve the use of traditional epidemiological techniques and causal inference methodologies alongside Mendelian randomization, colocalization and other genetic epidemiological methods to interrogate the causal role of the gut microbiome in the aetiology of several cancers including that of the colorectum, breast, prostate and lung among many others. Through this role, the post holder will have access to several large datasets comprising a mixture of individual-level genetic, microbiome and/or epidemiological data (e.g., the Flemish Gut Flora Project, the Avon Longitudinal Study of Parents and Children and UK Biobank) and large-scale GWAS consortia of the gut microbiome (e.g., the MiBioGen consortium) and cancer risk (e.g., the Genetics and Epidemiology of Colorectal Cancer Consortium for colorectal cancer) to undertake the research objectives. The post holder will work closely with a large range of researchers within ICEP and international collaborators including those at the International Agency for Research on Cancer, the institution of which the post holder will have the opportunity to spend time on extended visits during the post. You should apply if You have a strong background in molecular and genetic epidemiology, medical statistics and epidemiology, with experience using statistical programming languages (such as Stata and R) and working with large-scale genetic and other ‘omic datasets. Ideally, a successful applicant will also have experience of applied statistical analyses, genome-wide association study methodology and Mendelian randomization analyses. Additional information Contract type: Open-ended with funding until 31/12/2024 Work pattern: Full time/ 1 FTE Grade: Grade I - Pathway 2 Salary: £36,333 per annum Hours of work: 35 hours per week Department: Bristol Medical School For informal queries please contact: Kaitlin Wade ([email protected]) and Nicholas Timpson ([email protected]) Available documents School Information - BMS - October 2022.pdf ACAD107060 Research Associate in Molecular and Genetic Epidemiology JD.pdf JOB NUMBER ACAD107060 CONTRACT TYPE/WORK PATTERN Open ended / Full time CLOSING DATE 21 Aug 2023 FACULTY/DIVISION Faculty of Health Sciences SALARY £36,333 per annum